Faculty in Cancer Biology
Assistant Professor (Microbiology Immunology and Pathology, CVMBS). The focus of Dr. Regan’s laboratory is to increase our understanding of the interplay between the immune system and (non-immune) tumor stroma, and how these compartments of the tumor microenvironment promote metastasis as well as respond to and mediate extrinsic mechanisms of resistance to anti-cancer therapy. To investigate this area of cancer biology, his laboratory utilizes a combination of in vitro 3-dimensional tumor co-culture models and animal models, focusing on breast and bone cancer (osteosarcoma). Our long-term research goal is to fully elucidate the mechanisms by which tumors prime non-malignant host stromal cells of distant organs to promote their metastasis and chemo-resistance, in order to identify novel targets for host-directed stromal therapies which “poison the soil” for effective combination with conventional tumor cell targeted drugs.
Assistant Professor (Environmental & Radiological Health Sciences); Christian-Albrechts University, Germany (1995). Studies in the Wiese lab have the following emphasis: (1) to gain detailed information on the molecular mechanisms of DNA DSB repair processes that maintain genome integrity, and (2) to establish the links between new factors in DSB repair and their roles in cancer avoidance. We are using biochemical, structural and cell biological methods, in combination with mouse genetics, to tackle different aspects of DSB repair and genome maintenance mechanisms from molecules to mice.