Faculty in Neuroscience & Molecular Physiology
Assistant Professor (Biomedical Sciences); Ph.D., University of Nevada School of Medicine. The study of ion channels in arterial smooth muscle and their impact on arterial function. Changes in ion channel behavior during pathophysiological conditions such as hypertension
James R. Bamburg
Professor (Biochemistry and Molecular Biology); Ph.D. Wisconsin 1969. Regulation of the cytoskeleton in neuronal growth and pathfinding; signal transduction pathways regulating actin dynamics; abnormalities in actin behavior in neurodegenative diseases.
Professor (Chemistry and Microbiology, Immunology & Pathology); Ph.D. Yale 1971. Biomedical instrumentation; cellular immunology; molecular endocrinology.
Professor (Biochemistry & Molecular Biology); Ph.D. University of California, Berkeley 1980. Regulation of ubiquitin-dependent signaling, protein degradation by the 26S proteasome, and deubiquitination.
Associate Professor (Biomedical Sciences); Ph.D. University of Northern Colorado 2004. How changes in cardiac fatty acid metabolism and mitochondrial dysfunction contribute to the development and/or progression of heart disease, and how dietary and pharmaceutical interventions may modulate these processes.
Santiago Di Pietro
Assistant Professor (Biochemistry & Molecular Biology); Ph.D. University of Buenos Aires, Argentina 2001. Fundamental aspects of membrane protein transport.
Gregory L. Florant
Professor (Biology); Ph.D. Stanford 1978. Mammalian physiology; lipid metabolism and energetics.
William H. Hanneman
Associate Professor (Environmental & Radiological Health Sciences); Ph.D., Texas A&M, 1995. Developmental neurotoxicology,identification and characterization of developmental genes involved in response to hazardous environmental chemicals.
Ph.D., University of Zurich, 2005. The Hoerndli Lab overall research interest is in understanding how synapses dynamically regulate their molecular composition to give rise to synaptic learning and memory; and how these processes fail giving rise to neurological disorders or neurodegeneration. More specifically, we are interested in cell signaling mechanisms regulating synaptic Glutamate receptor transport delivery and removal. Indeed, Glutamate receptors play an essential role in excitatory synaptic transmission, learning and memory. Using the transparent genetic model organism C.elegans, I have established a microscopy platform that allows the direct visualization and manipulation of the transport, delivery and removal of synaptic glutamate receptors in whole intact animals. The research aims in the hoerndli lab are (1) identify cell signaling cascades regulating receptor loading onto Kinesin-1 motors at the cell body (2) identify cell signaling mechanisms regulating loading and unloading of receptors from molecular motors at synapses (3) determine the specific role and regulation of molecular transport in synaptic plasticity (4) identify cell signaling cascades modifying synaptic homeostasis during aging. Research in the Hoerndli lab will routinely use molecular cloning, genetics and forward genetic screens, in vivo spinning confocal microscopy, optogenetics, image/data analyses and behavioral analyses of C.elegans behavior.
Associate Professor (Biology); Ph.D. Texas A & M University, 1997. Enhance our understanding of molecular changes associated with hypoxia and translate these results for therapeutic applications in the treatment of myopathies.
Kim L. Hoke
Assistant Professor (Biology). Neural, developmental, and genetic mechanisms of behavior.
Associate Professor (Health & Exercise Science); PhD., University of California-Berkeley, 2002. Aging skeletal muscle and the regulation of mitochondrial and protein turnover.
Donald L. Mykles
Professor (Biology); Ph.D. California (Berkeley) 1979. Regulation of protein turnover; calcium-dependent and ATP/ubiquitin-dependent proteinases; myofibrillar proteins.
Kenneth F. Reardon
Professor & Associate Department Head (Chemical Engineering); Ph.D. California Institute of Technology 1988. Proteomics, systems biology, metabolic engineering, and enzyme-based biosensors.
Noreen E. Reist
Professor (Biomedical Sciences); Ph.D. Stanford University 1990; Molecular dissection of neurotransmitter release.
Michael M. Tamkun
Professor (Biomedical Sciences & Biochemistry Molecular Biology); Ph.D. Washington 1983. Ion channel molecular biology.
Professor (Microbiology, Immunology and Pathology); Ph.D. Carnegie Mellon University, 1990. Study the mechanism of prion replication, prion species barriers and strain diversity, and the molecular basis of inherited human prion diseases.
Ronald B. Tjalkens
Associate Professor (Environmental Radiological Health Sciences); Ph.D. University of Colorado Health Sciences Center 1998. Molecular neurotoxicology, regulation of nitric oxide synthase in mammalian astroglia, role of astroglial cells in parkinsonian syndromes.
Associate Professor (Biomedical Sciences); Ph.D., Washington University School of Medicine. 1995. Cellular strategies involved in the organization of signaling proteins and ion channels in neurons.
Stuart A. Tobet
Professor (Biomedical Sciences); Ph.D. M.I.T. 1985. Development and differentiation of the neuroendocrine brain.
Assistant Professor (Biomedical Sciences); PhD. Janus Pannonius University, Pecs, Hungary. Visual signal processing in the retina.
Associate Professor (Microbiology, Immunoloby & Pathology); Ph.D. University of Utah 2001. Prion immunology.